Have just downloaded the new software from Ambrosia called Soundboard and am mightily impressed:

"The concept of Soundboard is similar to the “cart machines” that once populated radio stations — devices that played back endless-loop tape cartridges used to play commercials, sound effects and other audio content. You can create libraries of audio clips using Soundboard, then trigger the effects by tapping hot keys on your Mac’s keyboard. You can drag in any audio file your Mac can play. Soundboard includes editing tools, and lets you apply effects or filters. Imported sounds are converted to Apple Lossless format to retain high fidelity and ensure instant playback. Soundboard can also be controlled using MIDI devices, with effects like panning and gain possible as well."

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Well as someone who used cart machines for many years at hospital radio, this really appealed. It is easy to use and is also a really cool way to file your sound effects, just drag and drop them and save. It's much easier to push one of the button to instantly preview it than to have to the click on a sound file and choose where to open it etc. It is going to make home recording so easy especially alongside the already overwhelming capabilities of Garage Band.

It's from the same folks as Wire Tap which is another simple application I can recommend.